The children were rummaging through the trash for food scraps and bottles in the southern province of Uruzgon when the blast killed them, police spokesman Farid Ayal said. A civilian man also died in the blast.
Four other children were wounded by the explosion in Trinkot, the provincial capital about 250 miles southwest of Kabul.
The U.N. estimates improvised bombs and suicide attacks accounted for half of nearly 1,500 civilian deaths in the first six months of last year, the most recent statistics.
Elsewhere in the south, four NATO troops died in one of Friday's bombings, and one was killed in a separate blast. The alliance said both incidents occurred in southern Afghanistan but provided no further details. It did not identify the troops or disclose what countries they came from.
The deaths bring to nine the number of international troops killed in the first week of the year. At least 544 NATO troops died in Afghanistan in 2011, the second-deadliest year for the coalition in the decade-old war.
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